Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme expression is induced by estrogen | Mus musculus | |
additional information | the enzyme expression is induced by estrogen | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of MMP-8 knockout mice by gene targeting, MMP-8-deficient female mice develop tongue squamous cell carcinoma at a significantly higher incidence than wild-type mice exposed to carcinogen 4-nitroquinoline-N-oxide, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | an MMP inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen + H2O | Mus musculus | - |
? | - |
? | |
Collagen + H2O | Homo sapiens | - |
? | - |
? | |
estrogen receptor alpha + H2O | Mus musculus | - |
? | - |
? | |
estrogen receptor alpha + H2O | Homo sapiens | - |
? | - |
? | |
estrogen receptor beta + H2O | Mus musculus | - |
? | - |
? | |
estrogen receptor beta + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Mus musculus | expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview | ? | - |
? | |
additional information | Homo sapiens | expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HSC-3 cell | - |
Homo sapiens | - |
OSCC cell | - |
Homo sapiens | - |
squamous cell carcinoma cell | induced by 4-nitroquinoline N-oxide | Mus musculus | - |
squamous cell carcinoma cell | induced by 4-nitroquinoline N-oxide | Homo sapiens | - |
tongue | - |
Mus musculus | - |
tongue | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen + H2O | - |
Mus musculus | ? | - |
? | |
Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
estrogen receptor alpha + H2O | - |
Mus musculus | ? | - |
? | |
estrogen receptor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
estrogen receptor beta + H2O | - |
Mus musculus | ? | - |
? | |
estrogen receptor beta + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview | Mus musculus | ? | - |
? | |
additional information | expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
collagenase-2 | - |
Mus musculus |
collagenase-2 | - |
Homo sapiens |
Matrix metalloproteinase-8 | - |
Mus musculus |
Matrix metalloproteinase-8 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Homo sapiens |